Preheat your oven to 375°F (190°C).

Combine ground beef, ground Italian sausage, breadcrumbs, eggs, garlic powder, onion powder, Italian seasoning, salt, and pepper in a bowl.

Mix mozzarella cheese, Parmesan cheese, and spinach in a separate bowl to create the cheese filling.

Flatten the meat mixture on parchment and spread the cheese filling, rolling it up tightly.

Place the rolled meatloaf seam-side down in a baking sheet and bake for 45-50 minutes.

Spread marinara sauce over the top during the last 10 minutes of baking.

Let the meatloaf rest for about 10 minutes before slicing and serving.