In a large skillet or deep fryer, pour enough vegetable oil to reach about 2 inches in depth. Heat the oil over medium-high heat until it reaches 375°F (190°C). To test the temperature, sprinkle a bit of flour into the oil; if it sizzles immediately, it's ready for frying your Southern Fried Shrimp.

In a mixing bowl, combine the raw, peeled, and deveined shrimp with milk and a pinch of salt, garlic powder, and paprika. Let the shrimp soak in this flavorful mixture for about 10 to 15 minutes.

While the shrimp is soaking, mix together the all-purpose flour, ground black pepper, dried oregano, and a bit more salt in a separate bowl.

Once the shrimp have marinated, remove them from the wet mixture, allowing any excess liquid to drip off. Dredge each shrimp in the seasoned flour mixture, ensuring they are well-coated.

Carefully add the coated shrimp to the hot oil in batches. Fry the shrimp for about 3 to 5 minutes or until they turn golden brown and float to the surface.

Once fried, gently remove the shrimp from the oil and place them onto a plate lined with paper towels to drain excess oil.

Serve the Southern Fried Shrimp hot, garnished with lemon wedges and your favorite condiments.